Wu Z, Yu J, Lin Q, et al. - Given that consecutive exposure to high-dose remifentanil during anesthesia may result in induction of remifentanil-induced postinfusion hyperalgesia (RPH), researchers here examined if in patients undergoing thyroidectomy under general anesthesia, an intraoperative bolus dose of intravenous dexmedetomidine could reduce RPH. They randomly assigned 90 patients undergoing thyroidectomy to 1 of 3 groups: placebo, normal saline (group P); low-dose dexmedetomidine 0.2 μg·kg⁻¹ (group LD); or high-dose dexmedetomidine 0.5 μg·kg⁻¹ (group HD). Outcomes revealed an alleviation of remifentanil-induced hyperalgesia in correlation with administering an intraoperative intravenous bolus dose of dexmedetomidine 0.5 μg·kg⁻¹ in patients undergoing thyroidectomy without a significant difference in side effects.