Nellis ME, et al. - In this secondary analysis of a prospective, observational study conducted at 82 PICUs in 16 countries, researchers investigated whether transfusing ABO compatible platelets had a greater influence on incremental change in platelet count than ABO incompatible platelets in critically ill children. Participants were children (3 d to 16 yr old) who received a platelet transfusion during one of the predefined screening weeks. They classified transfusions as either ABO compatible, major incompatibility, or minor incompatibility. A total of 342 (68%) received ABO-identical platelets, 133 (26%) received platelets with major incompatibility, and 28 (6%) received platelets with minor incompatibility. Findings revealed that the incremental change in platelet count, as well as the transfusion reactions compared between major ABO incompatible platelet transfusions vs ABO compatible transfusions, was not different between these two groups.