Hu J, et al. - Researchers investigated the role of Pregabalin (PGB) or gabapentin (GBP) in acute postoperative pain management. Via performing a comprehensive literature search of articles published by December 3, 2017, they included a total of 79 randomized controlled trials with 6,201 patients receiving single-dose premedication. Outcomes revealed a dose–response relationship in opioid consumption and postoperative pain for a single-dose preoperative administration of PGB and GBP. The occurrence of adverse reactions could be prevented via making reasonable choice of drugs and dosage.