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Effectiveness of Rotigotine plus intensive and goal-based rehabilitation vs Rotigotine alone in 'de-novo' Parkinsonian subjects: A randomized controlled trial with 18-month follow-up

Journal of Neurology Feb 17, 2018

Ferrazzoli D, et al. - An inquiry was carried out of the short and the long-term effectiveness of a multidisciplinary, intensive and goal-based rehabilitation treatment (MIRT) in a group of Parkinson’s disease (PD) patients treated with Rotigotine. The intention was to assess the synergism between Dopamine Replacement Therapy (DRT) and rehabilitation in the treatment of PD. Data illustrated that the effectiveness of Rotigotine + MIRT on the patients’ global clinical status, evaluated with total Unified Parkinson’s Disease Rating Scale (UPDRS) did not appear to be inferior to that of the pharmacological treatment with Rotigotine alone, over the course of 18 months. It was reported that rehabilitation enabled patients to gain better motor performances with lower DRT dosage.
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