Li X, Liu C, Mao Z, et al. - Whether Polymyxin B-immobilized hemoperfusion (PMX-HP) affords an efficacious as well as safe option against sepsis or septic shock, was investigated herein. Eligible randomized controlled trials were identified from PubMed, EMBASE and Cochrane Library databases. Researchers found 13 studies with 1163 patients. Findings demonstrated not only the safety but also the ability of PMX-HP in decreasing overall mortality when used to treat patients with less severe sepsis. Reduction in endotoxin levels as well as improvement in mean arterial pressure could be brought about by PMX-HP. A beneficial impact of reduction of endotoxin level and improvement of hemodynamics may be seen on treatment efficacy.