Catapano M, et al. - Experts performed a systematic review and meta-analysis of randomized controlled trials to investigate the efficacy and complication profile of platelet-rich plasma (PRP) injection into the carpal tunnel for management of carpal tunnel syndrome (CTS). They included a sum of 191 cases with a final follow-up of either 3 or 6 months. The titles, abstracts, and full texts extracting data from eligible studies were screened by two independent reviewers. PubMed, MEDLINE, SCOPUS, EMBASE, Google Scholar, Cochrane Central Register of Controlled Trials, and Web of Sciences (from inception to January 1, 2019) were searched. The individuals with mild to moderate CTS, PRP was found to be a promising therapy; nevertheless, included studies were limited as follow-up was short, the studies included individuals that were heterogeneous, and the number of included studies was low. To ascertain the true efficacy and impact of PRP and to better delineate the long-term results in individuals with CTS, future study is needed.