Arthur DW, Winter KA, Kuerer HM, et al. - Researchers investigated the efficacy and adverse effects of partial breast reirradiation after a second lumpectomy. Further, they assessed the acceptability of the treatment as an alternative to mastectomy. From June 4, 2010, to June 18, 2013, they conducted the NRG Oncology/Radiation Therapy Oncology Group 1014 trial, a phase 2, single-arm, prospective clinical trial of 3-dimensional, conformal, external beam partial breast reirradiation after a second lumpectomy for recurrence of breast cancer in the ipsilateral breast after previous whole breast irradiation. They assessed 58 patients with recurrence of breast cancer. Among these, the 5-year estimate of re-recurrence of breast cancer in the ipsilateral breast was 5%. In 7% of patients, they noted occurrence of late grade 3 treatment-related adverse events; no grade 4 or higher adverse events were reported. The 5-year cumulative incidence of ipsilateral mastectomy was 10%. Outcomes here indicate that for patients experiencing recurrence of breast cancer in the ipsilateral breast after an initial lumpectomy and whole-breast irradiation, a second lumpectomy followed by partial breast reirradiation is an effective alternative to mastectomy.