Conforti C, Giuffrida R, Dianzani C, et al. - In this retrospective study involving 72 patients who presented at the Dermatology Clinic of Maggiore Hospital of Trieste between November 1, 2019, and January 31, 2020, for the treatment of actinic keratoses (AKs), researchers sought to compare outcomes of three different topical therapies for patients with single AK (< 4): cryotherapy, CO₂ laser and 5‐fluorouracil 0.5% /salicylic acid 10%. According to findings, cryotherapy, CO₂ laser and 5‐FU 5%/SA 10% were all effective, with no major differences in efficacy between them. In addition, 5‐FU 5%/SA 10% was shown to have the best aesthetic outcome and to cause the least pain, while long-term administration was required. For patients with low pain tolerance and low adherence to treatment, this should be taken into consideration. The benefit of cryotherapy and CO₂ laser is that a single session is needed, which might be more appropriate for uncooperative patients.