Zhu X, et al. - Authors evaluated the symptomatic efficacy and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. In view of the efficacy of these symptomatic slow-acting drugs, experts noted a greater effectiveness of oral chondroitin vs placebo on relieving pain and improving physical function. An effect on stiffness outcome was demonstrated by glucosamine. Clinical decision making could be possible with this information accompanied with the tolerability and economic costs of included treatments.