Dani C, et al. - The possible effects of paracetamol on cerebral oxygenation and cerebral blood flow velocity (CBFV) for patent ductus arteriosus (PDA) was determined in preterm infants. The cerebral oxygenation was not affected by the treatment of hemodynamically significant PDA (hsPDA) with paracetamol in very preterm infants. No variations were reported in cerebral oxygenation in infants treated with paracetamol or ibuprofen. Nevertheless, in the ibuprofen group, the possible closure progression of PDA appeared to be linked to the changes of resistance index (RI).