Aravena PC, et al. - Researchers sought to determine the efficacy of warming anesthesia on the control of the pain produced during the administration of dental anesthesia injection. Moreover, they determined the role of Transient Receptor Potential Vanilloid-1 nociceptor channels in this effect. A significant attenuation in the pain was noted during the injection of anesthesia when it was used at 42°C vs at room temperature during maxillary injections. Also, it was suggested that the physiological mechanism of the temperature on pain reduction could be due to a synergic action on the permeabilization of the Transient Receptor Potential Vanilloid-1 channels, allowing the passage of anesthetic inside the nociceptors.