Fujii T, Luethi N, Young PJ, et al. - In order to find out whether the combination of vitamin C, hydrocortisone, and thiamine, compared with hydrocortisone alone, increases the duration of time alive and free of vasopressor administration in patients with septic shock, researchers performed multicenter, open-label, randomized clinical trial conducted in 10 intensive care units in Australia, New Zealand, and Brazil including a sum of 216 individuals between May 8, 2018, and the July 9, 2019. Individuals were assigned randomly to the intervention group (n = 109), consisting of intravenous vitamin C (1.5 g every 6 hours), hydrocortisone (50 mg every 6 hours), and thiamine (200 mg every 12 hours), or to the control group, consisting of intravenous hydrocortisone (50 mg every 6 hours) alone until shock resolution or up to 10 days. In comparison with intravenous hydrocortisone alone, they found that treatment with intravenous vitamin C, hydrocortisone, and thiamine does not lead to a more rapid resolution of septic shock.