Andersen LW, Isbye D, Kjærgaard J, et al. - The impact of administering the combination of vasopressin and methylprednisolone during in-hospital cardiac arrest on return of spontaneous circulation was investigated.

• A multicenter, randomized, double-blind, placebo-controlled trial.

• A total of 501 patients with in-hospital cardiac arrest in Denmark were included.

• Return of spontaneous circulation was achieved in 42% of patients in the combination group vs 33% in the placebo group, a difference that was statistically significant.

• Hence, the likelihood of return of spontaneous circulation increased significantly in correlation with receiving vasopressin and methylprednisolone, but uncertainty remains concerning if there is benefit or harm for long-term survival.