Milstone AM, Voskertchian A, Koontz DW, et al. - Researchers intended to investigate whether treating parents with intranasal mupirocin and topical chlorhexidine compared with placebo would decrease transmission of S aureus from parents to neonates. A double-blinded randomized clinical trial in 2 tertiary NICUs in Baltimore, Maryland was conducted to include a total of 236 neonates with S aureus–colonized parent(s) between November 7, 2014, and December 13, 2018. For 5 days, parents were allocated to intranasal mupirocin and 2% chlorhexidine–impregnated cloths (active treatment, n = 117) or petrolatum intranasal ointment and nonmedicated soap cloths (placebo, n = 119). In comparison with placebo, treatment with intranasal mupirocin and chlorhexidine-impregnated cloths significantly decreased neonatal colonization with an S aureus strain concordant with a parental baseline strain. Nevertheless, future study is required to replicate these findings and to evaluate their generalizability.