Nordberg P, et al. - In this randomized clinical trial involving 677 patients with out-of-hospital cardiac arrest, researchers ascertained if prehospital transnasal evaporative intra-arrest cooling improves survival with good neurologic outcome vs cooling initiated after hospital arrival. According to findings, transnasal evaporative intra-arrest cooling did not result in a statistically significant improvement in survival at 90 days with good neurologic outcome compared with usual care among patients with out-of-hospital cardiac arrest. The most common device-related adverse event was minor nosebleed.