Suarez-Kelly LP, et al. - Given that a significant decrease in seroma volume has been seen in an animal model evaluating microporous polysaccharide hemospheres (MPH, consists of hydrophilic, plant based, polysaccharide particles) and seroma formation after mastectomy with axillary lymph node dissection, researchers assessed the impact of topical MPH on the risk of post-mastectomy seroma formation as measured by total drain output and total drain days. Participants were 42 patients undergoing mastectomy for the treatment of breast cancer, control (n = 21) vs MPH (n = 21). In this patient population, the duration and quantity of serosanguinous drainage did not differ in association with the use of MPH, these findings were unlike the data presented in an animal model. An independent risk factor for high drain output was body mass index (BMI) greater than 30 and MPH use had no impact on this risk.