Brown CH, Neufeld KJ, Tian J, et al. - In this nested randomized clinical trial, researchers ascertained if targeting mean arterial pressure during cardiopulmonary bypass (CPB) utilizing cerebral autoregulation monitoring decreases the incidence of delirium compared with usual care. The study sample consisted of 199 participants [mean (SD) age was 70.3 (7.5) years]. According to results, delirium incidence (excluding coma) was significantly higher in the usual care group than in the group in which mean arterial pressure was targeted using cerebral autoregulation monitoring. The findings of this research indicate that optimizing mean arterial pressure to be higher than the lower cerebral autoregulation limit of the individual patient during CPB may decrease delirium incidence after cardiac surgery, but further research is required.