Philp L, Tannenbaum S, Haber H, et al. - Researchers performed this retrospective cohort analysis to investigate whether time to recurrence is impacted by surgical approach in early-stage high-intermediate risk endometrial cancer (HIR-EC) managed with adjuvant vaginal brachytherapy (VBT). They identified HIR-EC patients managed with VBT between 2005 and 2017, and participants were those who underwent open or minimally invasive hysterectomies (MIS). Higher BMIs, lower rates of lymph node sampling and lymphovascular space invasion were reported in open hysterectomy patients, however, among patients who recurred, there were no disparities between groups. Findings revealed that a shorter time to recurrence and higher risk of recurrence was observed in patients with HIR-EC managed with VBT following MIS hysterectomy vs open hysterectomy patients. There is a need for further investigations into the safety of MIS in high-intermediate risk patients.