Michalski JM, et al. - Whether radiation dose escalation to 79.2 Gy compared with 70.2 Gy would improve overall survival (OS) and other outcomes in prostate cancer, was investigated in this study. No improvement occurred in OS following dose escalation, however, improvements in biochemical failure and distant metastases were reported. With high doses, more late toxic effects but lower rates of salvage therapy were documented.