Vasikasin V, et al. - In this randomized, double-blind, placebo-controlled trial, researchers ascertained if standard dose paracetamol was effective as an antipyretic in dengue infection and if it caused transaminase elevation. Three Royal Thai Army hospitals in Thailand enrolled adult participants (aged ≥18 years) with dengue, confirmed by either positive NS1 antigen, positive dengue IgM antigen with thrombocytopenia, or positive PCR testing. One hundred twenty-five participants were randomly assigned to receive either paracetamol (n=63) or placebo (n=62) between September 1, 2016 and December 12, 2017. The intention-to-treat population included 123 participants. Without offsetting reduced fever or pain score, the use of standard dose paracetamol in dengue infection the incidence of transaminase elevation increased as well as overall transaminase concentrations. There was no death or liver failure in any patients.