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Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy

Sleep Medicine Oct 22, 2017

Dauvilliers Y, et al. - An exploratory analysis was pursued of the upshot of three narcolepsy treatment modalities on sleep stage shifts related to disrupted nighttime sleep (DNS). Sodium oxybate (SXB) with and without modafinil caused a substantial consolidation of sleep and improved the patient-reported sleep quality relative to placebo. On the other hand, no effects were reported with modafinil alone. This data indicated a specific influence of SXB on DNS along with its effect on daytime sleepiness.
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