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Effect of single‐ vs double‐layer uterine closure during cesarean section on postmenstrual spotting (2Close): Multicentre, double‐blind, randomized controlled superiority trial

BJOG: An International Journal of Obstetrics and Gynaecology Oct 29, 2020

Stegwee SI, van der Voet LF, Ben AJ, et al. - Via performing a multicentre, double‐blind, randomized controlled superiority trial, researchers here examined if double‐layer uterine closure after a first cesarean section (CS) is superior to single‐layer uterine closure with respect to postmenstrual spotting and niche development in the uterine cesarean scar. They randomly assigned a total of 2,292 women aged ≥ 18 years undergoing a first CS to each procedure (1:1): 1,144 women to single‐layer uterine closure and 1,148 women to double‐layer uterine closure. They assessed a total of 774 (67.7%) women from the single‐layer group and 770 (67.1%) women from the double‐layer group, who were evaluable for the primary outcome (number of days with postmenstrual spotting during one menstrual cycle 9 months after CS) as a result of drop‐out and amenorrhoea. Outcomes do not support the superiority of double‐layer closure to single‐layer closure in terms of postmenstrual spotting after a first CS. They suggest the necessity for long‐term obstetric follow‐up of this trial to assess whether uterine cesarean closure guidelines should be adapted.

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