Roffe C, et al. - This trial was formulated in order to ascertain the efficacy of routine prophylactic low-dose oxygen therapy over the control oxygen administration in reducing death and disability at 90 days. If this was established, this study would determine the efficacy of oxygen, given at night only, when hypoxia was most frequent, and when oxygen administration displayed the least tendency of interference with rehabilitation, over the continuous supplementation. A reduction was not reported in the death or disability at 3 months, among nonhypoxic patients with acute stroke, with the prophylactic use of low-dose oxygen supplementation. Hence, the use of low-dose oxygen, in such a scenario, was not supported.