Aeberli D, et al. - This research was conducted to evaluate the impacts of variations in the geometry and density of the metacarpal bone of individuals with rheumatoid arthritis (RA). Researchers conducted a prospective study to recruit consecutive postmenopausal RA individuals who met the American College of Rheumatology Criteria and healthy controls (HC). At baseline and follow-ups, they obtained peripheral quantitative CT scans at 50% of the total metacarpal shaft (third metacarpal bone). This study included 39 RA individuals and 42 consecutive postmenopausal healthy controls (HC) and these were followed for 63 months. It was noted that raise in medullary metacarpal CSA and thinning of the cortical CSA are physiological and time dependent. It was reported that RA status is correlated with loss in cortical density. The study suggested that low glucocorticoid dose influences metacarpal bone shaft geometry and density over time even upon biological therapy.