Yamamoto K, Shiomi H, Morimoto T, et al. - Researchers investigated the impact of stages of renal dysfunction on the ischemia-bleeding trade-off in patients with atrial fibrillation (AF) who were treated with percutaneous coronary intervention (PCI). They used a pooled database from three Japanese PCI studies. Based on renal function, they defined four groups of patients—creatinine clearance (CCr) > 60 mL/min: n = 703; 60 ≥ CCr > 30 mL/min: n = 627; CCr ≤ 30 mL/min: n = 126; and dialysis: n = 91. Overall, they noted a strong link between worsening renal function and an increasingly higher risk for bleeding events in AF patients receiving PCI, while only patients on dialysis had a significant excess risk for ischemic events.