Hausenloy DJ, Kharbanda RK, Møller UK, et al. - Researchers tested the influence of remote ischemic conditioning on the incidence of cardiac death and hospitalization for heart failure at 12 months in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) in this international investigator-initiated, prospective, single-blind, randomized controlled trial (CONDI-2/ERIC-PPCI) performed at 33 centers across the UK, Denmark, Spain, and Serbia. Using randomization, they assigned patients (age > 18 years) to receive standard treatment (including a sham simulated remote ischemic conditioning intervention at UK sites only) or remote ischemic conditioning treatment (intermittent ischemia and reperfusion applied to the arm by four cycles of 5-minute inflation and 5-minute deflation of an automated cuff device) prior to PPCI. Findings revealed no improvement in clinical outcomes (cardiac death or hospitalization for heart failure) at 12 months in relation to remote ischemic conditioning in patients with STEMI undergoing PPCI.