Ochsenreither JM, et al. – The physicians compared comfort levels and overall opioid use in full–term infants with congenital heart disease within 24 hours or less post–open heart repair. This retrospective study concluded that compared to infants who received IV opioid only (p < 0.08), infants prescribed rectal acetaminophen in conjunction with IV opioid had no significant difference in comfort levels. However, they had a statistically significant (p < 0.01) decrease in overall opioid exposure (0.11 mg/kg/day) as compared to infants prescribed IV opioid alone (0.28 mg/kg/day).