Valent AM, et al. - This study sought to determine rates of surgical site infection (SSI) among obese women who receive prophylactic oral cephalexin and metronidazole vs placebo for 48 hours following cesarean delivery. Among obese women undergoing cesarean delivery who received the standard preoperative cephalosporin prophylaxis, a postoperative 48-hour course of oral cephalexin and metronidazole, compared with placebo, reduced the rate of SSI within 30 days after delivery. This thereby justified using prophylactic oral cephalexin and metronidazole for prevention of SSI among obese women after cesarean delivery.