Lee YC, et al. - Researchers attempted to analyze if overnight orthokeratology affected the progression rate of the manifest refractive error of myopic children in a longer follow-up period (up to 12 years). Additionally, they examined the correlation between refractive changes and different baseline factors, including refraction error, wearing age and lens replacement frequency. It was deduced that overnight orthokeratology was effective in slowing myopia progression over a twelve-year follow-up period. It displayed a clinically acceptable safety profile. Initial higher astigmatism power exhibted a connection with an increased change of refractive error during follow-up years.