Kim Y, et al. - The impact of oral contraceptives (OC) over 1-year on the change in endocrine, metabolic and body composition profiles of women with polycystic ovary syndrome (PCOS) are assessed in this study. OC use more than 1 year could change androgen activity, lipid profiles and body composition for muscle and fat in PCOS women with normal BMI.

Methods

• For this research, they performed a cohort study.
• Total 187 of women with BMI<25 Kg/m² and PCOS by Rotterdam criteria were selected in this study.
• In this study, all subjective were follow-up to check endocrine, metabolic and body composition profiles with 1-year OC use.
• Endocrine and metabolic profiles were examined by serum sample and body composition profiles were checked utilizing multi-frequency bioelectrical impedance examination.
• Information were examined by Paired t-test and McNemar test where appropriate.

Results

• In this study, after 1-year utilization of OC, SHBG (100.6±95.6 nmol/L vs. 171.5±52.1 nmol/L, P=0.002) and DHEAs (192.3±88.4 μg/dL vs. 228.8±110.6 μg/dL, P=0.002) were increased, and testosterone (0.9±0.5 ng/mL vs. 0.6±0.4 ng/mL, P<0.001), 17-α-OHP (2.3±1.6 ng/mL vs. 1.2±0.7 ng/mL, P<0.001) and AMH (12.5±10.0 ng/mL vs. 10.8±8.5 ng/mL, P=0.011) were reduced.
• Utilizing 1-year OC increased total cholesterol (195.2±33.5 mg/dL vs. 201.8±32.5 mg/dL, P=0.007) and 25-OH vitamin D (16.2±9.5 ng/mL vs. 21.6±14.8 ng/mL, P=0.039).
• For body composition profiles, protein mass (10.3±1.1 Kg vs. 10.1±1.1 Kg, P=0.004), mineral mass (2.4±0.2 Kg vs. 2.3±0.2 Kg, P=0.004), muscle mass (38.5±4.0 Kg vs. 37.7±4.1 Kg, P=0.004), fat free mass (40.8±4.2 Kg vs. 40.1±4.3 Kg, P=0.006) and basal metabolic rate (1364.5±102.0 Kcal vs. 1330.9±107.0 Kcal, P<0.001) were reduced with 1-year OC use.
• With treatment of 1-year OC utilization, the proportion of women with abnormal free androgen index (≥5) was reduced 48.6% to 21.4% (P<0.001).
• The proportion of women with abnormal HOMA-IR (>2) and abnormal percent body fat (>28%) were similar (52.9% vs. 57.1% and 34.3% vs. 31.4%, P>0.05 in both).