Arhin SK, et al. – The goal of this study is to systematically summarize clinical evidence on the impact of micronutrients on primary outcome parameters of IVF treatment. Within the limits of this review, they observed micronutrients seem to affect positive outcomes in couples going through fertility treatment. Larger clinical studies are needed to strengthen these findings so that the benefit of micronutrients can be extended to subjects undergoing IVF therapy.

• For this study, they designed a systematic review of the literature.
• The literature was searched up to February 2017 through Embase and PubMed databases for relevant studies.
• The quality of qualified studies was evaluated with the Downs and Black checklist. A total of five studies qualified for inclusion.
• These studies reported outcomes on 467 participants administered micronutrient supplements alone or combined with other nutrients as part of IVF therapy.
• There was significant heterogeneity among the interventions and study designs.
• However, all the studies reported a positive effect of micronutrient supplementation on clinical outcomes of IVF therapy in terms of pregnancy rate and/or live birth rate.