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Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma

BMC Pediatrics Nov 17, 2019

Anuradha KWDA, Prematilake GLDC, Batuwita BAUI, et al. - In the present study, the researchers analyzed the impacts of long term inhaled corticosteroid therapy (ICS) on adrenal function, growth and bone health in children (aged 3 to 9 years) with asthma in comparison to age and gender-matched group of those with asthma who were not on long term ICS. In addition, they explored the connection between the dose of ICS and duration of therapy on the above parameters. The sample consisted of 70 children with asthma on ICS and 70 controls. According to published literature, the average daily dose of ICS (Beclamethasone) was categorized as low, medium and high (100–200, 200–400, > 400 μg /day) respectively. According to findings, ICS did not affect growth and bone profiles but its dose (> 400 μg/day) and duration (> 18 to 24 months) were significantly linked to adrenal suppression.
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