Jahanshahi J, et al. - In this triple-blinded clinical trial involving 90 subjects with chronic rhinosinusitis who were candidate for endoscopic sinus surgery, researchers assessed the impact of local nasal desmopressin premedication on blood loss and the quality of surgical field in functional endoscopic sinus surgery. Participants were randomly assigned to 2 study groups: one group got a single puff of local desmopressin (10 μg) in each side of nasal cavity 30 minutes before the surgery and the other took normal saline instead. In the desmopressin group, blood loss was significantly less than in the control group. Surgeons in the desmopressin group were more satisfied with the surgical field than with the control group at all cutoff points. During functional endoscopic sinus surgery, premedication with local desmopressin can efficiently decrease bleeding and clear the surgical field. No side effects with local desmopressin were noted.