Chang W, et al. - Authors sought to comprehensively assess the effects of levosimendan on mortality and clinical outcomes in severe sepsis and septic shock. The inclusion criteria involved studies related to the use of levosimendan in severe sepsis or septic shock compared with any category of inotropes, or as an adjunct to standard therapy with mortality reported. Data displayed that levosimendan use could reduce serum lactate more effectively, and enhance cardiac contractibility with increased cardiac index and left ventricular ejection fraction. Nonetheless, its use could increase fluid infusion but not reduce norepinephrine dose. Levosimendan vs dobutamine use did not reveal any significant benefit.