Fatt CRC, Jha MK, Cooper CM, et al. - Researchers investigated the predictive value of patterns of resting-state connectivity between brain regions for the differential outcome to antidepressant medication (sertraline) vs placebo. At baseline, structural and resting-state functional MRI was performed on participants in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care study. Either sertraline or placebo treatment was provided to participants for 8 weeks (N = 279). Findings yielded specific functional network–based moderators of treatment outcome involving brain networks that are known to be affected by major depression. In general, better outcomes, especially for sertraline, were predicted with higher connectivity within the default mode network, as with greater between-network connectivity of the default mode and executive control networks. In contrast, between-network hippocampal connectivity predicted both placebo and sertraline outcomes (in opposite directions).