Muto T, et al. - A total of 46 eyes of 44 subjects were analyzed to examine the influence of intravitreal aflibercept injection on the corneal endothelium in outpatients with diabetic or cystoid macular edema due to retinal vein occlusion. They observed no significant variations in the endothelial cell density (ECD), average cell size (AVG), standard deviation of cell size (SD), coefficient of variation of cell size (CoV), maximum of cell size (MAX), percentage of hexagonal cells (Hex%) and central corneal thickness (CCT) between measurements obtained before and 1, 3 and 6 months after the first injection. Although, they found a difference in values of the MAX before and 1, 3 and 6 months after the first injection. Overall, they concluded a mild alteration in corneal endothelium within 6 months of the first intravitreal administration of aflibercept (2 mg).