El Mourad MB, et al. - Given that hemodynamic alterations to pneumoperitoneum and postoperative pain can be detrimental in obese patients, researchers studied the impact of intravenous (IV) or intraperitoneal (IP) magnesium sulphate (MgSo₄) administration on hemodynamic stress response to pneumoperitoneum as well as on postoperative pain control following laparoscopic sleeve gastrectomy (LSG). This study included 120 patients scheduled for LSG. In a randomized manner, participants were assigned to either, control group (Group C, IV and IP saline), Group I (IV 30 mg/kg MgSo₄), or Group P (IP 30 mg/kg MgSo₄). According to the findings, the circulatory response to pneumoperitoneum was significantly reduced and postoperative pain as well as opioid intake were attenuated in relation to IV and IP administration of MgSo₄ vs controls, with no serious adverse effects, in this study sample of obese patients undergoing LSG.