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Effect of intraoperative dexamethasone on major complications and mortality among infants undergoing cardiac surgery: The DECISION randomized clinical trial

JAMA Jun 26, 2020

Lomivorotov V, Kornilov I, Boboshko V, et al. - Researchers investigated the effect of dexamethasone on complications and mortality in infants undergoing cardiac surgery via performing a randomized clinical trial involving 394 infants. No significant reduction was observed in the primary composite end point of death, nonfatal myocardial infarction, need for extracorporeal membrane oxygenation, cardiopulmonary resuscitation, acute kidney injury, prolonged mechanical ventilation, or neurological complications (38.1% vs 45.5%, respectively; hazard ratio, 0.82) in correlation to administering intraoperative of dexamethasone 1 mg/kg vs placebo to patients younger than 12 months undergoing cardiac surgery with cardiopulmonary bypass. .

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