Nadkarni GN, et al. - In this longitudinal analysis of a subgroup of 529 participants in Action to Control Cardiovascular Risk in Diabetes BP (ACCORD-BP) trial, researchers investigated whether the more rapid decline in estimated glomerular filtration rate (eGFR) shown in this trial following random assignment to intensive blood pressure (BP) lowering (systolic BP?<?120?mm?Hg) compared to a less intensive BP target (systolic BP?<?140?mm?Hg) reflected hemodynamic effects or intrinsic kidney damage. They observed reductions in eGFRs, but not an increase in injury marker levels in association with intensive BP control. According to findings, eGFR decline observed with intensive BP goals in ACCORD participants could mainly reflect hemodynamic alterations.