Bernardi D, et al. - This was a sub-study of the STORM-2 trial which prospectively assessed the impact of integrating digital breast tomosynthesis (3D-mammography) with acquired or synthetic 2D-mammography on radiologists’ true-positive (TP) and false-positive (FP) detection in a population screening trial. Participants in the study were asymptomatic women ≥49 years who attended population-based screening (Trento, 2013-2015) were enrolled. Although there was an overall pattern of increasing cancer detection and also increasing FP recall for most readers, there was variability in the magnitude of effect from integrating 3D-mammography (relative to screen-reading with acquired or synthesised 2D-mammography alone) on individual radiologist’s TP and FP detection.