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Effect of inhaled nitric oxide on survival without bronchopulmonary dysplasia in preterm infants: A randomized clinical trial

JAMA Pediatrics Nov 09, 2017

Hasan SU, et al. - Researchers scrutinized if the administration of inhaled nitric oxide to preterm infants requiring positive pressure respiratory support on postnatal days 5 to 14 improved the rate of survival without bronchopulmonary dysplasia (BPD). Safety was illustrated of the inhaled nitric oxide, initiated at 20 ppm on postnatal days 5 to 14 to high-risk preterm infants and continued for 24 days. Nevertheless, it did not improve survival without BPD at 36 weeks’ PMA or respiratory and neurodevelopmental outcomes at 18 to 24 months’ postmenstrual age (PMA).
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