Schmitz KH, Troxel AB, Dean LT, et al. - Via a randomized clinical trial of 351 overweight breast cancer survivors with lymphedema, researchers evaluated weight loss, home-based exercise, and the combination of weight loss and home-based exercise with clinical lymphedema outcomes. Mean (SD) total upper extremity score variations from the objective clinical assessment were −1.40, −24.5, −3.54, and −3.84 in the control group, the exercise group, the weight loss group, and the combined group, respectively. Mean (SD) overall upper extremity score variations from the self-report survey were −0.39, −0.12, −0.57 and −0.62 in the control group, the exercise group, the weight loss group, and the combined group, respectively. Weight loss from baseline was −0.55%, −8.06%, −7.37%, and −0.44% in the control group, the combined group, the weight loss group, and the exercise group, respectively. In conclusion, weight loss, home-based exercise, and combined interventions did not enhance breast cancer–related lymphedema outcomes and a supervised facility-based program of exercise may be more advantageous in comparison with a home-based program for improving lymphedema outcomes.