Ospina-Tascón GA, Calderón-Tapia LE, García AF, et al. - Researchers investigated the necessity for intubation and time to clinical improvement among patients with severe COVID-19 in correlation with the use of high-flow oxygen therapy through a nasal cannula, vs conventional oxygen therapy.

• A randomized clinical trial including 220 patients with severe COVID-19.

• Those treated with high-flow oxygen therapy through a nasal cannula vs with conventional oxygen therapy had intubation and mechanical ventilation rate of 34.3% vs 51.0%, respectively.

• The median time to clinical recovery was 11 days vs 14 days.

• Findings suggest reduced likelihood of invasive mechanical ventilation and decreased time to clinical recovery among patients with severe COVID-19 in correlation with receiving treatment with high-flow oxygen therapy vs conventional oxygen therapy.