Bridoux F, et al. - A comparative assessment was carried out by the authors of the hemodialysis independence rate among patients newly diagnosed with myeloma cast nephropathy treated with hemodialysis, with the aid of a high-cutoff dialyzer (with very large membrane pores and high permeability to immunoglobulin light chains) or a conventional high-flux dialyzer (with small pores and lower permeability). It was deduced that the use of high-cutoff hemodialysis compared with conventional hemodialysis did not lead to a statistically marked variation in hemodialysis independence at 3 months, among patients with myeloma cast nephropathy treated with a bortezomib-based chemotherapy regimen. Nonetheless, this research could have been underpowered to detect an early clinically significant difference.