Lind MV, et al. – In this study, researchers assessed the impact of folate supplementation on insulin resistance (IR) and type 2 diabetes (T2D) outcomes. They analyzed evidence from 29 randomized controlled trials (RCTs; n=22,250) that reported on fasting glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), or risk of T2D, in relation to placebo-controlled folate supplementation alone or in combination with other B vitamins. They noted lowered fasting insulin and HOMA-IR with folate supplementation vs placebo, with no overall effects observed for fasting glucose or HbA1c. Except for change in homocysteine, no signs of effect modification were observed in subgroup analysis; trials with a change of > 2.5 µmol/L demonstrated the most pronounced effects. Overall, the authors indicated that it may be beneficial to go for folate supplementation for glucose homeostasis and lowering IR, but no conclusions could be drawn regarding its effect on development of T2D.