Askarpour M, Karimi M, Hadi A, et al. - Researchers analyzed data from 40 eligible randomized controlled trials (RCTs), involving 2,520 participants, to assess the effectiveness of flaxseed supplementation on significant adhesion molecules and inflammatory cytokines in adults. The included RCTs reported the influences of flaxseed supplementation on the circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), vascular cell adhesion protein 1 (VCAM-1), E-selectin, and intercellular adhesion molecule 1 (ICAM-1), and were identified from PubMed, Scopus, Web of Science, and Google Scholar databases. As per the findings of meta-analysis, flaxseed supplementation caused a decline in the levels of CRP, IL-6, and VCAM-1 but did not significantly influence TNF-α, ICAM-1, and E-selectin. This demonstrates the possible ability of flaxseed in improving some circulating levels of particular adhesion molecules and inflammatory cytokines when consumed as a supplement.