Callum J, Farkouh ME, Scales DC, et al. - Researchers examined the efficacy of fibrinogen concentrate vs cryoprecipitate for treatment of bleeding related to hypofibrinogenemia after cardiac surgery via performing a randomized trial of 735 adult patients who underwent cardiac surgery and developed clinically significant bleeding and hypofibrinogenemia post cardiopulmonary bypass. In the fibrinogen concentrate group and the cryoprecipitate group, the mean number of blood components transfused within 24 hours post bypass was 16.3 units and 17.0 units, respectively; ratio of the mean number of units transfused was 0.96, which met the prespecified noninferiority margin ratio of less than 1.2. Based on the findings, they suggest that consideration could be given to fibrinogen concentrate for fibrinogen replacement in the management of cardiac surgery-associated bleeding related to acquired hypofibrinogenemia.