Oji M, Koyama Y, Oshika H, et al. - In view of a previous finding of a strong and significant inhibitory effect of endotracheal tube (ETT) cuff lubricated with K-Y jelly on the increase in cuff pressure during nitrous oxide (N₂O) exposure in vitro, and a previous investigation revealing significant differences between some influential factors as well as addressing temperature variations between laboratory and clinical conditions, researchers focused on the truth of this effect in clinical settings. Firstly, they inquired about the impact of changes in the amount of K-Y jelly and temperature on the inhibitory impacts of the lubricant on the rise in N₂O-induced cuff pressure in vitro. They also questioned if the use of K-Y jelly inhibits the rise in ETT cuff pressure during general anesthesia using N₂O in adult patients. In the laboratory studies, a dose-dependent inhibitory effect of K-Y jelly on the cuff pressure increase was seen when the dose of K-Y jelly was varied, and reduction of this inhibitory effect was noted with an increase in the studied temperature. Overall, the increase in cuff pressure during general anaesthesia with N₂O may be delayed by lubricating ETT cuff with K-Y jelly, however, this effect may have limited clinical significance.