Effect of different doses of aspirin on the prognosis of kawasaki disease
Pediatric Rheumatology Jun 17, 2020
Wang J, Chen H, Shi H, et al. - This study was undertaken to investigate the impacts of different doses of aspirin on the prognosis of Kawasaki disease. Researchers retrospectively examined a sum of 2,369 patients with Kawasaki disease and categorized into three groups according to the aspirin dose: 510 in group 1 (20–29 mg/kg/day), 1,487 in group 2 (30–39 mg/kg/day), and 372 in group 3 (40–50 mg/kg/day). They compared differences in laboratory data, rate of intravenous immunoglobulin resistance and coronary artery damage among the groups. In comparison with the dose of 30–50 mg/kg/day, aspirin at the dose of 20–29 mg/kg/day dose not increase the risk of coronary artery damage and intravenous immunoglobulin resistance. It was demonstrated that this low dose may have a lower risk for a potential impact on liver function.
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