Zhuang P, Liu X, Li Y, et al. - Adherence to a healthy diet was linked to greater reductions in blood HbA _1c levels and subsequent type 2 diabetes (T2D) risk in people with a higher genetic risk. The findings support tailoring dietary recommendations for T2D prevention to an individual's genetic make-up.

• Between 2006 and 2010, 357,419 people were enrolled and prospectively tracked up to 2017 with genetic and comprehensive dietary data from the UK Biobank.

• During an average of 8.1 years of follow-up, 5,663 incident T2D patients were documented.

• Between the genetic risk score (GRS) and the diet quality score, there was a significant negative interaction.

• After controlling for significant risk factors, each SD increase in the GRS and the diet quality score was linked to a 54% greater and a 9% lower incidence of T2D, respectively.

• Due to the antagonistic interaction, an increase of 1 SD in both the diet quality score and the GRS was also linked to a 3% decreased T2D risk.

• In categorical analyses, participants in the extremely high GRS group (GRS > 95%) saw a substantial reduction of 23% in T2D risk linked with a 1-SD increase in diet quality score.

• At baseline, there was also a strong negative interaction between the GRS and the diet quality score on blood HbA _1c levels.